
Royce da 5'9" has released two remixes of it, one by himself and one with fellow Slaughterhouse members Joe Budden, Crooked I, and Joell Ortiz. Rappers AZ and Jay Rock have also both recorded remixes. Kelly for using the effect on a previous mixtape. Renamed "Death of Autotune Kellz", it was directed at artist R. On June 9, R&B artist Trey Songz released an unofficial remix of the song on his blog. The video ranked at #17 on BET's Notarized: Top 100 Videos of 2009 countdown. It did not win either of the categories, losing to T.I.'s " Live Your Life" and Eminem's " We Made You" respectively. The video was nominated for Best Male Video and Best Hip-Hop Video at the 2009 MTV Video Music Awards. Basketball player LeBron James also makes a cameo appearance.

Actor Harvey Keitel cameos in the video as a card player in the kitchen of New York's exclusive restaurant, Rao's. The video shows Jay in scenes such as a deserted factory building, a bar with a band, and playing card games in a kitchen. The music video (directed by Anthony Mandler) was shot and aired immediately after the 2009 BET Awards on June 28. On June 27, 2009, a trailer for the video was released. Jay-Z sampled a portion of The Notorious B.I.G.'s freestyle "Wake Up Show Freestyle". song " You're Nobody ('Till Somebody Kills You)". The song makes a reference to The Notorious B.I.G. The title is also a reference to the medical term "D.O.A." or " Dead on Arrival". It made him feel that what was once a trend had become a gimmick.

One of the partial inspirations for Jay-Z to write the song was hearing Auto-Tune being used in an advertisement for Wendy's fast-food chain. Jay-Z himself stated that the point of the song was to "draw a line in the sand", saying that while he appreciated the use of the Auto-Tune by artists with an ear for melody like T-Pain and Kanye West, far too many people had jumped onto the technology and were using it as a crutch. They then removed all the songs that contained Auto-Tune from The Blueprint 3 to further their point. and thought about making an anti-Auto-Tune song. However, Kanye heard the instrumental by No I.D. (Death of Auto-Tune)", Kanye West and Jay-Z had recorded an Auto-Tune song.
